The hepatocyte growth factor/scatter factor and its receptor MET, has a unique biological role in embryogenesis, tissue regeneration and cancer. A recent work employing Protein Tomography contributes to the ongoing projects aimed at producing MET antagonists for cancer therapy.
View protein tomograms in 3-D
Structural basis of hepatocyte growth factor/scatter factor and MET signalling
Ermanno Gherardi, Sara Sandin, Maxim V. Petoukhov, John Finch, Mark E. Youles, Lars-Göran Öfverstedt, Ricardo N. Miguel, Tom L. Blundell, George F. Vande Woude, Ulf Skoglund, and Dmitri I. Svergun.
PNAS 2006 103: 4046-4051; March 14, 2006.
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